I generally see 4-tower speakers setup symmetrically, if you compare this to a distributed subwoofer setup it's obviously a lot more limited, so the room has to be more of a consideration. As Mike says above, purpose-built room > full integration > fully coherent. If you're going to invest in a 6-figure 4-tower speaker setup putting effort into the room or using a purpose built room seems logical, if not then YMMV for sure. You can't separate bass performance from the room.