That depends on the circuit. Obviously the power supply or supplies are a good place to look.
If we are talking about a set of MA-1s the first thing I would do is make sure the amp is up to date. If that is done then the coupling caps are the first thing to look at, although in the MA-1 if its been updated to latest spec that's already taken care of. Does this amp have the resistor package (Caddock) or the Power Supply Boost options?