Let's see - you are using two well known logical fallacies in your post
Not really. I specified the aynchronous mode via galvanically-isolated link.
If you are saying that it would still be affected by the software, then what further steps need to be taken to eliminate this variability? If you don't think this is possible, then we have found a case where formal engineering claimed to have solved a problem, but thanks to the tireless efforts of audiophiles, we have discovered it had not. In this case the effect is audible ("night and day") but not, apparently, measurable. In other cases it may be the difference between an aircraft staying in the air or falling out of the sky.
If instead of a link within the same room we send the bits over wi fi, or a microwave link, or the internet, what steps would we need to take to
eliminate any audible or measurable contamination from the medium or the software used? If we can't, I say it's a pretty big failure of engineering!